Nanomedicine Unit

Research Interests:

The major focus of the laboratory is on the development of novel gene delivery systems to achieve an appropriate vector for gene therapy.

Developing polymer-based (especially PEI-based) gene delivery systems.

The objective of these studies is to achieve novel non-viral vectors with an improved ability of getting gene inside cells.

Developing peptide-based non-viral gene delivery systems.

The emphasis of these studies is to design vectors, which cannot serve many functions that other types of non-viral vectors can not perform alone.

Liposome-based delivery of gene using different approaches

Preparation and evaluation of nano-sized lipoplexies as a non-viral in gene therapy: effect of bilayer fluidity of cationic liposome’s on transfection efficiency.

Preparation and evaluation of glactosylated lipoplexes as non-viral vector: effect of cholesterol derivatives on transfection efficiency.

Future Projects:

Application of recombinant fusion proteins for gene delivery.

Because of having precise composition, sequence and length, these types of vectors can be good options for cancer gene therapy.

 

Lines of Research   Dr. Mahmoud Reza Jaafari Targeted drug delivery, nanomedicine, liposomal drug delivery,Cancer treatment using nanoliposomes containing cytotoxic drugs,  topical liposomes for the treatment of leishmaniasis, liposome based vaccination against cancer and leishmaniasis, liposome based nucleic acid delivery peptide and protein formulation Dr. Mohammad Ramezani Nanomedicine (Design and synthesis of gene delivery vectors based on polycations, carbon nanotubes and hybride peptides) Dr. Mohsen Tafaghodi Mucosal and systemic vaccine and drug delivery by nanoparticulate and microparticulate delivery systems (nanospheres, microspheres and liposomes) Dr. Shiva GolMohamadzadeh (Ph.D) Topical and parental drug targeting by Nanoliposomes, SLN, NLC, Formulation of cosmetic and toiletries products, SPF determination of sunscreens Dr. Ali Badiee Targeted drug and/or vaccine nanodelivery systems, Peptide and protein formulation, Liposome based vaccination, Liposomal drug/gene delivery Dr. Bizhan Malaekeh-Nikouei Particulate drug delivery systems including Microspheres and Nanospheres, Liposomes, Solid lipid nanoparticles (lipospheres Designing of non-viral vectors, Targeted drug delivery, Peptide and protein formulation, Instrumental analysis Dr. Maryam Hashemi Development of polymer based nanoparticles (non viral vectors) for plasmid DNA and siRNA transfer Formulation of recombinant protein and actine natural products based nanoparticle